MKP2 Pure 48/MKP2 50ug

产品编号：BD-610850 品牌：BD-Pharmingen 原厂货号：610850
产品分类：抗体 > 一抗 > 蛋白特异性一抗
应用分类：

包装：

50ug

运保温度:

Store undiluted at -20°C.

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描述：

The mitogen activated protein (MAP) kinases mediate signal transduction pathways involved in cellular growth and differentiation. These

MAP kinases, including ERK1 and ERK2, are activated by phosphorylation on Tyr and Thr by MEK (MAP and ERK Kinase). Regulation of

the resulting physiological effects of MAP Kinase activation is affected in part by

MAPK inase phosphatases (MKPs). These phosphatases

have dual specificity, dephosphorylating both the tyrosine and threonine residues on MAP kinases. MKP2, which is widely expressed in

human tissues, specifically dephosphorylates activated ERKs and JNK. These phosphatases have overlapping substrate specificities for the

three known families of MAP kinases - p38, ERK, and JNK. All of the known MKPs contain a highly conserved carboxyl-terminal catalytic

domain flanked by two CH2 (CDC25 homology 2) domains.

注意事项：

1.Since applications vary, each investigator should titrate the reagent to obtain optimal results.
2.Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing.
3.Store undiluted at -20°C.