Rab8 Pure 4/Rab4 150ug

产品编号：BD-610845 品牌：BD-Pharmingen 原厂货号：610845
产品分类：抗体 > 一抗 > 蛋白特异性一抗
应用分类：

包装：

150ug

运保温度:

Store undiluted at -20°C.

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描述：

The members of the Ras superfamily of GTPases, which now includes more than 50 different proteins, shuttle between the GDP-bound

inactive position and the GTP-bound active state. The GTPase activity of the Ras-like proteins is regulated by effectors that promote either the

GDP- or the GTP-bound states. GTPases of the Ras superfamily have a role in controlling numerous events such as cell proliferation,

nucleocytoplasmic transport, and vesicular traffic. The Rab superfamily of proteins includes more than 30 different members that are involved

in the regulation of different steps of vesicular traffic. Subcellular localization and specific cellular function of each Rab appears to be encoded

in the unique C-terminal part of the proteins, known as the hypervariable region. The 207 amino acid Rab8 protein is closely related to the

yeast Sec4p and regulates vesicle transport from the Trans-golgi Network to the basolateral plasma membrane in epithelial cells. In addition,

Rab8 interacts with the stress-activated kinase rab8p, a close homologue of the GC Kinase. This interaction was found to be dependent on

GTP.

注意事项：

1.Since applications vary, each investigator should titrate the reagent to obtain optimal results.
2.Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing.
3.Store undiluted at -20°C.