Smad2/3 Pure 18/Smad2/3 150ug

产品编号：BD-610843 品牌：BD-Pharmingen 原厂货号：610843
产品分类：抗体 > 一抗 > 蛋白特异性一抗
应用分类：

包装：

150ug

运保温度:

Store undiluted at -20°C.

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描述：

The transforming growth factor β(TGFβ)/activin/BMP family of growth factors plays a diverse and important role in growth, development,

and differentiation. These growth factors act through their binding to heteromeric plasma membrane receptor protein kinases which, upon

ligand binding, become activated and trigger an intracellular signaling cascade. Specifically, receptor activation induces the translocation of a

set of conserved proteins named Smads (Sma- and Mad-related proteins) to the nucleus, resulting in gene activation. Smad2 is a ubiquitously

expressed protein of 58 kDa that is phosphorylated and translocated to the nucleus in response to TGF

, but not BMP. The overall response to

TGF

is growth inhibition. The Smad2 gene is located in chromosome 18q21.1 which is often absent in several human cancers. Furthermore,

some missense mutations on the Smad2 gene were identified in colorectal carcinomas, suggesting Smad2 may function as a tumor suppressor

in normal cells.

Investigators should note that potential crossreactivity to Smad3 is predicted based on sequence homology of the immunogen, Mouse Smad2

aa. 142-263. In addition, reactivity to mouse Smad2, using siRNA knockdown, has recently been described (Dzwonek

et al.). Reactivity to canine Smad3 has also been reported using nuclear extracts (Lehman

et al.).

注意事项：

1.Since applications vary, each investigator should titrate the reagent to obtain optimal results.
2.Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing.
3.Store undiluted at -20°C.