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p62 Lck Ligand Pure 3 50ug

  • 产品编号:BD-610832      品牌:BD-Pharmingen       原厂货号:610832
  • 产品分类:抗体 > 一抗 > 蛋白特异性一抗
  • 应用分类:
 
包装: 50ug
运保温度: Store undiluted at -20°C.
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描述:

p62 lck ligand (zeta-interacting protein (ZIP)) is a cytoplasmic protein that binds to the SH2 domain of lck (a T cell src tyrosine kinase) in the
absence of a phosphotyrosine in either protein. The ubiquitously expressed p62 lck ligand contains a cysteine rich region that is similar to a
zinc finger domain, a G protein binding region, a PEST sequence, and several phosphorylation sites. Deletion of the p62 lck ligand N-terminal
domain has been reported to abrogate its binding to lck. However, mutation of the tyrosine did not have an effect. In addition, p62 lck ligand
binds to the pseudosubstrate region of the PKC
ζ
catalytic domain. In turn, PKCζ
phosphorylates p62. p62 lck ligand binds to the dimerization
region of PKCζ, thereby inhibiting PKCζ-PKCζinteraction. This suggests that p62 lck ligand may compete with PKCζ. However, it requires
PKCζfor proper subcellular localization. These data suggest that p62 lck ligand may be part of the protein bridge that links PKCζ to the
tyrosine kinases involved in signaling pathways.


注意事项:

1.Since applications vary, each investigator should titrate the reagent to obtain optimal results.
2.Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing.
3.Store undiluted at -20°C.


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