收藏本站
热门搜索: A3500  E1910  A1360  25200056  dmem  

CD11a Pure 27/CD11a 150ug

  • 产品编号:BD-610827      品牌:BD-Pharmingen       原厂货号:610827
  • 产品分类:抗体 > 一抗 > 蛋白特异性一抗
  • 应用分类:
 
包装:
运保温度: Store undiluted at -20°C.
到货周期: 登录后查看
标准价: ¥客户可见
会员价: ¥客户可见
积分: 客户可见
 
登录之后可加入购物车购买,请您 
对比 收藏

运费与支付说明:

1.含干冰类产品有运费;

2. 必须现金付款或有信用额度的会员才可以直接发货,否则需要等待现金付款信息。

描述:

CD11a, also known as integrin αL or LFA-1 (lymphocyte function-associated antigen
-1), is a member of the β2 family of integrins that
includes Mac-1 and p150,95. It is composed of two noncovalently linked α and β chains which are associated with the actin cytoskeleton.
CD11a (integrin αL) has been reported to be expressed on the surface of T cells, neutrophils, and macrophages. It is involved in cell-cell
adhesion and it also conveys signals from the plasma membrane to the cytoplasm. Activation of the TCR/CD3 complex on T cells transmits
intracellular signals that activate integrin αL (“inside-out” signaling). This results in the conformational change of integrin αL, which increases
its affinity for its ligand ICAM-1,-2, and -3. Furthermore, this signaling releases integrin αL from the actin cytoskeleton, resulting in clustering
of this surface molecule. The high affinity conformation and the clustering of integrin αL increases the adhesion between it and ICAM. This
adhesion is essential for leukocyte activation and results in “outside-in” signaling which induces the polymerization of actin, thereby
stabilizing the integrin αL-ICAM interaction. This interaction is necessary for CTL and NK mediated killing, T and B cell responses, ADCC,
and immune cell extravasation.


注意事项:

1.Since applications vary, each investigator should titrate the reagent to obtain optimal results.
2.Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing.
3.Store undiluted at -20°C.


相关图片

本产品可用于的实验

购此产品的人还购买了
最近浏览产品

京ICP备15036693号-2    京公网安备11010802025653    版权所有:北京逸优科技有限公司       2.46

 纠 错