Caspase-7 Pure 51/Caspase-7/MCH-3 50ug

产品编号：BD-610812 品牌：BD-Pharmingen 原厂货号：610812
产品分类：抗体 > 一抗 > 蛋白特异性一抗
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包装：

运保温度:

Store undiluted at -20°C.

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描述：

Apoptosis is induced by cysteine proteases which include Ced-3 of C.elegans, Caspase-3 (also known as CPP32, Yama, or apopain), and
DCP-1 of Drosophila.. Multiple signals, such as activation of Fas and granzyme B, activate Caspase-3 which, in turn, cleaves substrates. Some
substrates of Caspase-3 are PARP, MCH-3, MCH-2, U1-associated 70kDa protein, and SREBPs. Caspase-7/MCH-3 is a putative cysteine
protease cloned from human Jurkat T lymphocytes. This protein shows significant homology to mammalian interleukin-1β -converting enzyme
(ICE), Caspase-3, and the Caenorhabditis elegans protein Ced3. All three of these proteins are cytoplasmic cysteine proteases that induce
apoptosis when overexpressed in different cell types. This apoptosis can be inhibited by coexpression of Bcl-2. Similar to ICE and Caspase-3,
Caspase-7 is a proenzyme that is proteolytically cleaved into p20 and p12 subunits that form the active Caspase-7 heterodimeric complex.
Similarity to ICE and Caspase-3, as well as its high levels observed in lymphocytes, suggests that Caspase-7 plays an important role in
immunologic apoptosis.

注意事项：

1.Since applications vary, each investigator should titrate the reagent to obtain optimal results.
2.Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing.
3.Store undiluted at -20°C.