Eps15 Pure 17/eps15 50ug

产品编号：BD-610806 品牌：BD-Pharmingen 原厂货号：610806
产品分类：抗体 > 一抗 > 蛋白特异性一抗
应用分类：

包装：

50ug

运保温度:

Store undiluted at -20°C.

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描述：

The eps15 (EGF receptor pathway substrate clone number 15) gene was isolated using an expression cloning method designed for direct
isolation of cDNAs encoding substrates of tyrosine kinases. The eps15 gene encodes a 145 kDa protein that is tyrosine phosphorylated
following EGF receptor activation and this receptor directly phosphorylates purified Eps15 in vitro. Phosphorylation of Eps15 is much more
efficient following EGF receptor activation versus erbB2 kinase activation, suggesting the protein is predominantly a part of an EGF receptor
signaling pathway. Overexpression of Eps15 causes transformation of NIH 3T3 cells, implying Eps15 may be involved in the control of cell
proliferation. Eps15 binds to the SH3 domain of Crk through its proline-rich domain at the C-terminal region. Adaptin α binds to the
C-terminus of Eps15 at three different sites ranging from residues 650 to 730. Eps15, Adaptin α, and EGF receptor are co-localized at the
clathrin-coated pits after receptor activation. Therefore, Eps15 may recruit EGF receptors to the clathrin-coated pits for internalization of the
activated receptor.

注意事项：

1.Since applications vary, each investigator should titrate the reagent to obtain optimal results.
2.Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing.
3.Store undiluted at -20°C.