Plakophilin 2 Pure 28/Plakophilin 50ug

• 产品编号：BD-610788      品牌：BD-Pharmingen       原厂货号：610788
• 产品分类：抗体 > 一抗 > 蛋白特异性一抗
• 应用分类：

描述：

Plakophilin 2 is a desmosomal plaque protein that belongs to the "arm" repeat family of proteins. Alternative splicing results in two isoforms:
2a (837 aa) and 2b (881 aa). The 2b isoform contains an insertion of 44 aa in the arm repeat unit 2. Other arm family members are ß-catenin,
plakophilin 1, plakoglobin, pp120, and armadillo of Drosophila gene product. They have at least 9 repeats of the arm motif, which consists of
approximately 42 aa, and a short carboxyl terminus. Plakophilins are constitutively expressed in desmosome-containing cells. Plakophilin 1
has been found only in desmosomal-containing cells, such as stratified and complex epithelia. Plakophilin 2 has been isolated from both
desmosomal as well as non-desmosomal forming cells, including simple and glandular epithelia, and from nonepithelial tissues such as the
mycocardium and Purkinje fibers. In addition, Plakophilin 2 is found in the karyoplasm of interphase cells. Plakophilins 2a and 2b are part of
desmosomal plaques, although they are located primarily in the karyoplasm of the interphase nucleus. The function of nuclear plakophilin 2
remains to be identified.

原厂资料：

注意事项：

1.Since applications vary, each investigator should titrate the reagent to obtain optimal results.
2.Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing.
3.Store undiluted at -20°C.