ARF3 Pure 41/ARF3 50ug

• 产品编号：BD-610784      品牌：BD-Pharmingen       原厂货号：610784
• 产品分类：抗体 > 一抗 > 蛋白特异性一抗
• 应用分类：

描述：

The ADP-ribosylation factors (ARFs) belong to the multigene family of small GTPases capable of activating cholera toxin. ARFs fall into
three different classes: Class I is composed of ARF-1, ARF-2, and ARF-3; Class II consists of ARF-4 and ARF-5; and Class III includes
ARF6. Unique to ARFs is their lack of intrinsic GTP hydrolysis activity, a high affinity for GDP in a Mg2+-dependent manner, and
phospholipid requirement for nucleotide exchange. ARFs are involved in intravesicular acidification of microsomal vesicles, endosome
fusion, nuclear membrane assembly, and formation of clathrin-coated vesicles. In addition, GTP and ARF-3 are required for the activation of
phospholipase D (PLD), an early cellular response triggered by the binding of receptors on the cell surface in response to numerous
extracellular signals. Although predominantly cytosolic, ARF-3 can be translocated to cellular membranes upon cellular stimulation. The
transition between the GDP-bound ARF-3 to the GTP-ARF-3 is facilitated by a high molecular weight guanine nucleotide-exchange factor
sensitive to brefeldin. ARF-3 has been reported to be the most abundant in brain, kidney, and liver.

原厂资料：

注意事项：

1.Since applications vary, each investigator should titrate the reagent to obtain optimal results.
2.Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing.
3.Store undiluted at -20°C.