CASK Pure 7/CASK 50ug

• 产品编号：BD-610782      品牌：BD-Pharmingen       原厂货号：610782
• 产品分类：抗体 > 一抗 > 蛋白特异性一抗
• 应用分类：

描述：

CASK is a recently identified cytosolic protein kinase with homology to the Ca2+/CaM-dependent kinases and the synaptic associated
proteins SAPs/PSDs. Like the SAPs, CASK contains a PDZ domain, an SH3 region, and a guanylate kinase domain. However, unlike the rest
of the PDZ protein family, the amino terminus of CASK has significant homology with the Ca2+/Calmodulin-dependent kinases. Although
widely expressed, CASK is highly enriched in the synaptic plasma membrane where it associates with neurexins, the neuronal cell surface
proteins. Neurexins are a complex family of surface proteins that act as receptors for a number of venoms and toxins and regulate the
clustering of several ion channels at the synapse. In addition, neurexins bind heterotypically to neuroligins, therefore adjoining different cell
types. Neuroligins bind intracellularly to PSD95 and related proteins, whereas neurexins bind to CASK through their C-terminal region and at
CASK's PDZ domain. The interaction of neurexins and CASK at the outside of the cell may modulate CASK's activity and trigger an
intracellular signaling cascade.

原厂资料：

注意事项：

1.Since applications vary, each investigator should titrate the reagent to obtain optimal results.
2.Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing.
3.Store undiluted at -20°C.