RON Alp Pure 29/RON Alp 150ug

产品编号：BD-610745 品牌：BD-Pharmingen 原厂货号：610745
产品分类：抗体 > 一抗 > 蛋白特异性一抗
应用分类：

包装：

运保温度:

Store undiluted at -20°C.

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描述：

RON (Recepteur d'Origine Nantaise) is a tyrosine kinase receptor for MSP (Macrophage Stimulating Protein) that belongs to the hepatocyte
growth factor receptor family. RON is synthesized as a single chain glycosylated polypeptide of 1400 amino acids that is cleaved upon
maturation into a 150 kDa β-subunit with the kinase activity and a 40 kDa α-chain. Both chains are linked by disulfide bonds and the proper
arrangement of the α and β heterodimer is necessary for biological activity of RON. MSP induces the tyrosine kinase activity of RON,
triggering a cascade of intracellular signaling that leads to DNA synthesis. However, RON activation in mouse erythroleukemia cells results in
apoptosis. The replacement of autophosphorylation sites Y1330 and Y1337 abolishes both the mitogenic and apoptotic effects of MSP.
Therefore, autophosphorylation at Y1330 and Y1337 is required for RON's biological activity. PLCγ, Shc, Grb2, p61, and p65 associate with
RON. Although widely expressed, RON is particularly abundant in epithelial tissues, lung, brain, adrenal glands, gastrointestinal tract, kidney,
and testis.

注意事项：

1.Since applications vary, each investigator should titrate the reagent to obtain optimal results.
2.Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing.
3.Store undiluted at -20°C.