Glutathione-S-Transferases (GSTs) are a family of dimeric proteins that catalyze the S-conjugation of glutathione with many compounds for
detoxification. The GSTs are categorized into four classes based on their biochemical and structural properties: α, μ, π, and θ. GST-π is of
particular interest because it is over-expressed in many tumors, but is either absent or expressed at low levels in the corresponding normal
tissues. This high expression of GST-π is associated with malignant transformation and correlates with a decrease in GST activity. Three
different GST-π proteins have been isolated and designated as hGSTP1*A, hGSTP1*B, and hGSTP1*C. These isoforms are nearly identical,
varying by only one to two amino acids.
原厂资料:
注意事项:
1.Since applications vary, each investigator should titrate the reagent to obtain optimal results.
2.Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing.