BM28 Pure 46/BM28 50ug

产品编号：BD-610700 品牌：BD-Pharmingen 原厂货号：610700
产品分类：抗体 > 一抗 > 蛋白特异性一抗
应用分类：

包装：

50ug

运保温度:

Store undiluted at -20°C.

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描述：

BM28 is a phosphoprotein that migrates at 125kDa in SDS PAGE with a hyperphosphorylated form migrating as a slightly slower band. The

ratio of the phosphorylation states alters with the phases of cell cycle - in M, the "fast" phosphorylated BM28 is the major form found, while

in G1 phase, the "slow", hyperphosphorylated BM28 predominates. The cellular localization of BM28 is also cell cycle dependent. In G1,

most of the BM28 is chromatin bound, whereas, by M phase, the BM28 is still nuclear, but not associated with the DNA. BM28 is necessary

for both entry into S phase and cell division as determined by microinjection inhibition experiments. Microinjection of a BM28 antibody into

synchronised cells in G1 phase inhibits DNA replication. When injected during S phase or later, no effect on DNA replication is seen, but cell

division is inhibited.

注意事项：

1.Since applications vary, each investigator should titrate the reagent to obtain optimal results.

2.Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing.