NF-κB is a transcription factor that regulates many cytokine and Ig genes involved in immune response, inflammation, and viral infections.
NF-κB is induced by cytokines and lipopolysaccharide (LPS), but is inhibited by glucocorticoids. IκBα/MAD-3 inhibits the DNA-binding
activity of NF-κB and related transcription factors. In THP-1 monocytic-like cells, LPS induces the phosphorylation and inactivation of IκBα,
which results in the activation of NF-κB. Therefore, phosphorylation of IκBα may induce the dissociation of the IκBα/NF-κB complex.
原厂资料:
注意事项:
1.Since applications vary, each investigator should titrate the reagent to obtain optimal results.
2.Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing.