Synapsin IIa Pure 1/Synapsin IIa 50ug

Synapsins are a group of four related proteins (synapsin Ia, Ib, IIa, and IIb) found exclusively in neuronal tissues. The four identified

synapsins originate by alternative splicing of the mRNA from two different genes (synapsin I and II). Phosphorylation of synapsins occurs

concomitantly with membrane excitation and neurotransmitter release into the synaptic cleft. Synapsins bind to the synaptic vesicles through

their amino terminal domain, which also contains phosphorylation sites for the cAMP-dependent protein kinase. In vitro, synapsins bundle

actin filaments. This indicates that synapsins may cross-link the vesicles with the actin filaments at the presynaptic terminal. By using

hippocampal neurons and specific anti-sense oligonucleotides to block synapsin IIa expression, it was found that synapsin IIa was essential for

the formation of synapses.

1.Since applications vary, each investigator should titrate the reagent to obtain optimal results.

2.Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing.