L-Caldesmon Pure 8/L-Caldesmon 50ug

产品编号：BD-610660 品牌：BD-Pharmingen 原厂货号：610660
产品分类：抗体 > 一抗 > 蛋白特异性一抗
应用分类：

包装：

50ug

运保温度:

Store undiluted at -20°C.

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描述：

Caldesmon is a protein component of the thin filaments of smooth muscle myofibrils. It is also localized in the stress fibers of fibroblasts.

Caldesmon was identified as a Ca2+/Calmodulin-binding protein with molecular weight of 120-150 kDa (H-Caldesmon) and 70-80 kDa

(L-Caldesmon). H-Caldesmon is the primary isoform in smooth muscle while L-Caldesmon is most abundant in non-muscle cells. Caldesmon

is capable of binding two calmodulin molecules, one at either end of the protein. Additionally, Caldesmon is an actin, myosin, and

tropomyosin-binding protein. Human L-Caldesmon is a protein of 538 amino acids with mobility of 80 kDa. In vitro , L-Caldesmon inhibits

the actomyosin ATPase in an F-Actin-dependent manner. L-Caldesmon may play an important function in motile processes such as secretion

and organelle movement.

注意事项：

1.Since applications vary, each investigator should titrate the reagent to obtain optimal results.

2.Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing.