KAP3 (kinesin superfamily-associated protein 3) was identified as an accessory protein for the microtubule translocator kinesin and,
independently, as SMAP (Smg GDS-associated protein). Alternative splicing of KAP3 mRNA results in proteins of 793 amino acids (KAP3A)
and 772 amino acids (KAP3B). KAP3 protein reportedly is highly expressed in brain and testis and displays an apparent molecular weight of
100 kDa. Analysis of its primary structure reveals that KAP3A contains nine repeats of the Arm domain (40 amino acids). This domain is
characteristic of the Armadillo family of proteins that includes armadillo, β-catenin, plakoglobin, importin, APC, and pp120. In addition,
KAP3/SMAP is a substrate for v-src kinase. Phosphorylation of KAP3/SMAP decreases its assocation with Smg GDS.
原厂资料:
注意事项:
1.Since applications vary, each investigator should titrate the reagent to obtain optimal results.
2.Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing.