Pleckstrin was identified in platelets as a major substrate for Protein Kinase C. Both ends of the molecule are the prototypes of a widely
distributed module named the "pleckstrin homology" (PH) domain that consists of seven β-strands. In pleckstrin, the PH domains are
separated by 150 amino acids. PH domains are commonly found in signal transduction proteins. Although pleckstrin's role is still poorly
defined, PH domains are widely used by receptors for interaction with G proteins and for membrane attachment. It is thought that PH domains
regulate the binding of pleckstrin to membranes and modulate phosphoinositide metabolism by its binding to G proteins.
原厂资料:
注意事项:
1.Since applications vary, each investigator should titrate the reagent to obtain optimal results.
2.Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing.