Integrins are membrane receptors that mediate cell-cell or cell-matrix adhesion. All integrins are transmembrane heterodimers composed of α
and β subunits and are connected to the cytoskeleton. At least 20 integrins, formed from combinations of 12 α and 9 β subunits, have been
reported. Many of these have been implicated as transducers of molecular signals. The β1 subgroup of this receptor family comprises at least
six different dimer combinations. Among these combinations, α2β1 is associated with type I collagen and laminin binding and regulation,
α3β1 is a receptor for laminin and epiligrin, and α5β1 is a fibronectin receptor. β1 integrins play an important role in several aspects of
epidermal differentiation and morphogenesis. Expression of the β1 subunit is regulated by growth factors such as TGF-β1. Integrin activation,
which enhances binding of T cells to endothelium, is regulated in part by phosphatidylinositol 3-kinase. Focal adhesion kinase (FAK) and
paxillin have been reported to independently bind the C-terminal, cytoplasmic domain of the β1 subunit. FAK is reported to be enzymatically
activated upon engagement of integrins with their ligands and paxillin is phosphorylated on tyrosine upon activation of FAK.
原厂资料：
注意事项：
1.Since applications vary, each investigator should titrate the reagent to obtain optimal results.
2.Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing.
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