p96 Pure 52/p96 50ug

CSF-1 is a growth factor that stimulates the growth and differentiation of immature lymphocytes and is required for the survival of

mononuclear phagocytes. Binding of CSF-1 induces dimerization and autophosphorylation of its receptor. This results in the activation of

several signal transduction pathways. A unique 96 kDa protein is a component in the CSF-1 signal transduction cascade. p96 is

phosphorylated on serine following mitogenic stimulation of a mouse macrophage cell line. p96 contains three potential C-terminal ERK kinase

phosphorylation sites, as well as several proline-rich sequences that are potential binding sites for SH3-containing proteins. Structural

similarities have been found between p96 and Dab, a product of the Drosophila disabled gene, and p96 was also identified as Disabled-2

(Dab-2) and as differentially expressed in ovarian carcinoma-2 (DOC-2) . Dab-2/p96 has been shown to be essential for TGFβ signaling by

facilitating signal transduction from the TGFβ receptor to the Smad family of transcription factors. Thus, Dab-2/p96 is an important adaptor

molecule in growth factor signaling pathways.

1.Since applications vary, each investigator should titrate the reagent to obtain optimal results.

2.Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing.