Microtubule-associated proteins (MAPs) play a crucial role in the development and structure of nerve cells. These proteins are important for
the assembly and stability of microtubules during neurite outgrowth and for the morphology of neuronal processes, such as dendrites, MAP2,
specifically localized in dendrites, has four known isoforms produced by alternative splicing of the transcript. These isoforms, MAPs A, B, C,
and D, are expressed at various stages of neuronal development. MAP2B is a 280-kDa protein expressed throughout brain development. It is
composed of several highly conserved domains that are flanked by domains with extensive sequence divergence. An N-terminal conserved
domain overlaps with a binding domain for the regulatory subunit of the cAMP-dependent kinase II, while a C-terminal conserved domain
overlaps with a microtubule-binding domain. Secondary structure prediction suggests that the portion of MAP2B extending from the
microtubule surface is composed of a number of alpha-helices separated by small turns which may account for the extended, yet flexible,
structure of MAP2B.
原厂资料：
注意事项：
1.Since applications vary, each investigator should titrate the reagent to obtain optimal results.
2.Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing.
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