EEA1 Pure 14/EEA1 50ug

产品编号：BD-610456 品牌：BD-Pharmingen 原厂货号：610456
产品分类：抗体 > 一抗 > 蛋白特异性一抗
应用分类：

包装：

50ug

运保温度:

Store undiluted at -20° C.

到货周期：

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描述：

Early endosomes are a major cytoplasmic sorting compartment from which receptors and ligands may be distributed to various sites within the

cell. Early endosome antigen 1 (EEA1) is a 180 kDa hydrophilic peripheral membrane protein present in cytosol and membrane fractions.

Immunofluorescence studies show that EEA1 colocalizes to early endosomes with transferrin receptor and Rab5, but not with the late

endosome-localizing Rab7. EEA1 is predominantly α-helical and shares 17-20% sequence identity with the myosins. It contains a

calmodulin-binding IQ motif and metal-binding cysteine "finger" motifs. It is thought that EEA1 is required for vesicular transport of proteins

through early endosomes and that these finger motifs are required for this activity.

注意事项：

1.Since applications vary, each investigator should titrate the reagent to obtain optimal results.

2.Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing.