B2 Bradykinin Receptor Pure 20 150ug

Bradykinin is a nine amino acid vasoactive peptide that elicits numerous physiologic responses such as vasodilation, smooth muscle spasm,

and pain. Bradykinin is one of a family of such peptides called the kinins. The kinins are generated from high molecular weight precursors

called kininogens from proteolysis induced by pathophysiologic conditions such as inflammation or allergy. The physiological actions of these

kinins are mediated by their interaction with transmembrane receptors. There are two distinct bradykinin receptor subtypes: B1 and B2. Both

are coupled to G-proteins. The B2 receptor subtype is found in healthy smooth muscle cells and neurons, whereas, the B1 receptors are only

detected following tissue injury. The B2 receptor is similar in structure to other seven helix G-protein coupled receptors. Bradykinin has a

relatively low affinity for B1 receptors, and interacts primarily with the B2 receptor. This interaction stimulates several second messenger

systems, including inositol phospholipid hydrolysis, arachidonic acid metabolism, tyrosine phosphorylation, and membrane depolarization and

hyperpolarization.

1.Since applications vary, each investigator should titrate the reagent to obtain optimal results.

2.Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing.