Brm Pure 24/BRM 50ug

产品编号：BD-610389 品牌：BD-Pharmingen 原厂货号：610389
产品分类：抗体 > 一抗 > 蛋白特异性一抗
应用分类：

包装：

50ug

运保温度:

Store undiluted at -20°C .

到货周期：

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描述：

Several of theSNF and SWI genes of

Saccharomyces cerevisiae

encode proteins that are involved in the regulation of transcriptional

activation. One of these proteins, SNF2/SWI2, has both

Drosophila

and mammalian homologues, designated

brm

. The human Brm protein

has been reported to be a 180 kDa nuclear factor that acts as a transcriptional activator when fused to a heterologus DNA binding domain.

Transfected Brm, expressed in cells lacking endogenous protein, can cooperate with the glucocorticoid receptor (GR) in transcriptional

activation. The cooperation between Brm and GR requires the DNA binding domain of GR and the helicase domain and the P/Q-charged

domain of Brm. However, Brm does not affect on several other transcription factors. The retinoblastoma protein, Rb, stimulates the

transcription of a number of genes. Like Brm, Rb up-regulates glucocorticoid-receptor-mediated transcription. Brm and Rb interact

in vitro

and

in vivo

, requiring the Rb-pocket domain and the consensus Rb-binding motif of Brm.

This antibody is routinely tested by western blot analysis. Other applications were tested at BD Biosciences Pharmingen during antibody

development only or reported in the literature.

注意事项：

1.Since applications vary, each investigator should titrate the reagent to obtain optimal results.
2.Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing. .
3.Store undiluted at -20°C .