Adaptin Bta Pure 74/Adaptin Bta 50ug

产品编号：BD-610381 品牌：BD-Pharmingen 原厂货号：610381
产品分类：抗体 > 一抗 > 蛋白特异性一抗
应用分类：

包装：

50ug

运保温度:

Store undiluted at -20°C .

到货周期：

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描述：

Sorting of integral membrane proteins at various stages of the endocytic and secretory pathways is mediated by vesicular trafficking between a

variety of organelles. Two sorting signals are tyrosine-based and dileucine-based signals that interact with heterotetrameric adaptor protein

complexes (AP-1, AP-2, AP-3, and AP-4), which are associated with the vesicle coats. These coatomers contain two large Adaptin proteins (

γ,α,δ, or ε and β 1β2,β

3, or β 4, respectively) that are noncovalently linked to one medium chain (μ1, μ2, μ3, or μ4) and one small chain (

σ1,σ2,σ3, orσ4). The AP-1 and AP-3 complexes are involved in protein sorting from the TGN and endosomes, while AP-2 adaptor complexes

are involved in clathrin-mediated endocytosis.β

Adaptin subunits (

β1,β2,

β3,β

4) lack sequence homology to adaptinsα,γ,δ, and ε, but all of

these subunits share a similar domain structure. Adaptin β

1 (also known as Adaptin

β') andβ2 (also known as Adaptinβ) have 83% amino

acid identity and are found in the AP1 and AP2 complexes, respectively.

注意事项：

1.Since applications vary, each investigator should titrate the reagent to obtain optimal results.
2.Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing. .
3.Store undiluted at -20°C .