LAR Pure 7/LAR 50ug

产品编号：BD-610350 品牌：BD-Pharmingen 原厂货号：610350
产品分类：抗体 > 一抗 > 蛋白特异性一抗
应用分类：

包装：

50ug

运保温度:

Store undiluted at -20°C .

到货周期：

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描述：

	The Leukocyte common Antigen-Related (LAR) receptor protein tyrosine phosphatase (RPTP) is one of approximately 20 known, distinct

	transmembrane RPTPs. LAR consists of an extracellular region with three Ig-like and eight fibronectin type III-like (FNIII) domains and a

	cytoplasmic region containing two tyrosine phosphatase domains typical of RPTPs. The Ig and FNIII domains of LAR show some sequence

	similarity to domains in the neural cell adhesion molecule N-CAM, a neural surface glycoprotein which mediates cell adhesion and neurite

	outgrowth. Studies suggest that LAR regulates neurite outgrowth and pathfinding during neural development. N-CAM and other cell

adhesion molecules that affect neurite outgrowth, such as L1, TAG-1, and fasciculin II, lack intrinsic kinase or phosphatase activity. Thus,

LAR is part of a distinct class of proteins with both cell adhesion and tyrosine phosphatase functions. LAR transcripts are alternatively spliced

and that splicing is regulated during development. It is postulated that the various spliced forms of LAR each have specialized functions in the

nervous system and play a role in neural development and regeneration.

注意事项：

1.Since applications vary, each investigator should titrate the reagent to obtain optimal results.
2.Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing. .
3.Store undiluted at -20°C .