DAP Kinase Pure 17/DAP Kinase 50ug

产品编号：BD-610290 品牌：BD-Pharmingen 原厂货号：610290
产品分类：抗体 > 一抗 > 蛋白特异性一抗
应用分类：

包装：

50ug

运保温度:

Store undiluted at -20°C .

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描述：

Chronic exposure to extracellular signals such as interferons induce the inhibition of cell proliferation followed by cell death. The gene for

DAP Kinase (

Death A ssociatedProtein Kinase) was identified using a novel approach named Technical Knockout. Briefly, Hela cells were

transfected with an antisense cDNA expression library, then exposed to Interferon-γ. The surviving cells, with their antisense cDNAs, were

rescued and the "protecting" genes isolated. The DAP Kinase gene encodes a protein of 1423 amino acids, a molecular weight of 160kDa, a

kinase domain at its amino terminal region, ankyrin repeats in the middle region, and a death domain at the extreme C-terminus. DAP Kinase

phosphorylates at Ser/Thr residues in a Ca2+/Calmodulin-dependent fashion. It has been demonstrated that Ca2+/Calmodulin binds directly to

DAP Kinase at its amino terminal region. In addition, immunostaining studies localized DAP Kinase in association with the actin filaments

where it may phosphorylate myosin light chain. Thus, this novel cytoskeletal and Ca2+/Calmodulin-dependent protein kinase plays a role in

interferon-γ-induced cell death.

注意事项：

1.Since applications vary, each investigator should titrate the reagent to obtain optimal results.
2.Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing. .
3.Store undiluted at -20°C .