ISGF3 Gma Pure 6/ISGF3 Gma 50ug

产品编号：BD-610285 品牌：BD-Pharmingen 原厂货号：610285
产品分类：抗体 > 一抗 > 蛋白特异性一抗
应用分类：

包装：

50ug

运保温度:

Store undiluted at -20°C .

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描述：

ISGF3γ is a nuclear DNA-binding protein. ISGF3 (Interferon Stimulated Gene Factor-3) is the primary transcription activator induced by the

binding of interferon α (IFNα) to cell surface receptors. The functional ISGF3 is a complex of four polypeptides of 113 kDa (Stat2), 91 kDa

(Stat1α), 84 kDa (Stat1β), and 48 kDa. The first three polypeptides (also known as ISGF3γ) each contain SH2 and SH3 domains. In response

to either IFNα, IFNγ, EGF, PDGF, or CSF-1 binding their respective receptors, the cytoplasmic ISGF3α subunits are tyrosine-phosphorylated

and translocated to the nucleus where they form an active complex with the 48 kDa protein (ISGF3γ). This complex is responsible for

modulating the transcription of interferon-stimulated genes (ISGs). Activated ISGF3α stabilizes ISGF3γ-DNA interactions. This results in a

ternary protein-DNA complex with a 25-fold greater stability than ISGF3γ-DNA. Thus, growth factors and cytokines activate a common signal

transduction pathway that leads to the phosphorylation and nuclear translocation of a group of latent cytoplasmic transcription factors.

注意事项：

1.Since applications vary, each investigator should titrate the reagent to obtain optimal results.
2.Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing. .
3.Store undiluted at -20°C .