eIF-4E Pure 87/eIF-4E 150ug

产品编号：BD-610270 品牌：BD-Pharmingen 原厂货号：610270
产品分类：抗体 > 一抗 > 蛋白特异性一抗
应用分类：

包装：

150ug

运保温度:

Store undiluted at -20°C .

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描述：

The eukaryotic translation initiation factor 4E (eIF-4E) is a 25 kDa phosphoprotein that specifically binds to the

7-methylguanosine-containing cap of mRNA. eIF-4E is the rate-limiting component for the initiation of cap-dependent translation by the

eIF-4E translation initiation complex. This complex promotes the unwinding of secondary structure at the 5' untranslated region of mRNA,

which is necessary to expose and locate the AUG-initiation codon. Phosphorylation of eIF-4E on Ser-209 occurs after serum treatment in

CHO cells, and may regulate its function. Overexpression of eIF-4E can lead to increased cell proliferation, transformation, and tumorigenesis

in nude mice. The overexpression of a Ala-53 variant of eIF-4E cannot evoke these changes, suggesting that Ser-53 on eIF-4E participates in

the transfer of mRNA to the 48S initiation complexes. In cooperation with nuclear oncogenes such as

c-myc

E1A

, eIF-4E transforms

primary cells. Other studies have demonstrated that overexpression of eIF-4E causes activation of Ras and leads to a transformed phenotype.

Subsequent overexpression of GAP then causes reversion of this phenotype. The mechanism by which eIF-4E plays a role in transformation is

not clear, but it is postulated that high levels of eIF-4E may lead to the translation of mRNAs that are normally translationally repressed.

注意事项：

1.Since applications vary, each investigator should titrate the reagent to obtain optimal results.
2.Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing. .
3.Store undiluted at -20°C .