Dynamin II Pure 27/Dynamin II 150ug

产品编号：BD-610264 品牌：BD-Pharmingen 原厂货号：610264
产品分类：抗体 > 一抗 > 蛋白特异性一抗
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包装：

运保温度:

Store undiluted at -20°C .

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描述：

Dynamin is a membrane-associated GTPase that binds to GTP, microtubules, and phospholipids. Northern blot analysis has shown dynamin to

be present in most tissues but at an amount about 20-fold lower than that in brain. There are at least two distinct dynamin genes in mammals.

Transcripts of both dynamin genes are alternatively spliced at two or more sites. The first site is identical in both dynamins, whereas, the

second site differs. The two gene products are known as Dynamin I and Dynamin II and show 79% identity. Dynamin I is expressed almost

exclusively in the central nervous system while Dynamin II expression is ubiquitous. The two proteins are highly homologous in the

N-terminal region, while the C-terminal domain shows significant divergence. The GTPase activity of Dynamin I is stimulated several fold by

binding to microtubules, phospholipids, and membranous vesicles. Dynamin I is a good substrate of PKC in vitro as well as in vivo in resting

nerve terminals. In vitro, phosphorylation occurs at the C-terminus of Dynamin I and this enhances the GTPase activity more than 10-fold.

However, Dynamin II is not a substrate of PKC and its activity does not appear to be affected by phosphorylation. These data suggest that the

function of the common N-terminal domain between Dynamin I and II may be differentially specified by distinct C-terminal domains.

注意事项：

1.Since applications vary, each investigator should titrate the reagent to obtain optimal results.
2.Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing. .
3.Store undiluted at -20°C .