PKC Theta Pure 27/PKC Theta 50ug

产品编号：BD-610089 品牌：BD-Pharmingen 原厂货号：610089
产品分类：抗体 > 一抗 > 蛋白特异性一抗
应用分类：

包装：

50ug

运保温度:

1.Since applications vary, each investigator shou

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描述：

The Protein Kinase C (PKC) family of homologous serine/threonine protein kinases is involved in a number of processes, such as growth,

differentiation, and cytokine secretion. At least eleven isozymes have been described. These proteins are products of multiple genes and

alternative splicing. PKC consists of a single polypeptide chain containing four conserved regions (C) and five variable regions (V). The

N-terminal half containing C1, C2, V1, and V2 constitutes the regulatory domain and interacts with the PKC activators Ca2+, phospholipid,

diacylglycerol, or phorbol ester. However, the novel PKC (nPKC) subfamily members (δ, ε, η, and θ isoforms) and the atypical PKC (aPKC)

subfamily members (ζ, ι, and λ isoforms) are Ca2+-independent and lack the C2 domain. The aPKC members are unique in that their activity

is independent of diacylglycerols and phorbol esters. They also lack one repeat of the cysteine-rich sequences that are conserved in cPKC and

nPKC members. The C-terminal region of PKC contains the catalytic domain. The PKC pathway represents a major signal transduction system

that is activated following ligand-stimulation of transmembrane receptors by hormones, neurotransmitters, and growth factors. PKCθ

transcripts are expressed in most tissues with the highest levels being found in hematopoietic tissues and cell lines, including T cells and

thymocytes. PKCθ mRNA is readily detectable in skeletal muscle, lung and brain. However, PKCθ expression is not detected in several human

carcinoma cell lines. Abundant expression of this PKC isozyme in hematopoietic cells suggest that it may have a role in growth and

differentiation processes of these cells.

注意事项：

1.Since applications vary, each investigator should titrate the reagent to obtain optimal results.
2.Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing. .
3.Store undiluted at -20°C .