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Hu CD8 BV711 RPA-T8 25Tst

Hu CD8 BV711 RPA-T8 25Tst

产品编号：BD-563676 品牌：BD-Pharmingen 原厂货号：563676
产品分类：抗体 > 一抗 > 染料标记抗体
应用分类：

包装：

25Tst

运保温度:

Store undiluted at 4°C

到货周期：

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描述：

The RPA-T8 monoclonal antibody specifically binds to CD8 alpha (CD8α). CD8α

is a type I transmembrane glycoprotein and a member of

the immunoglobulin superfamily. CD8α

is expressed by the majority of thymocytes, by subpopulations of αβ

T cells and γδ T cells and by some NK cells. Cell surface CD8α is expressed either as a disulfide-linked homodimer (CD8αα or as a heterodimer (CD8 αβ) when

disulfide-bonded to a CD8 beta chain (CD8β). CD8-positive αβ

T cells coexpress both CD8 αα homodimers and CD8α

heterodimers whereas

some γδ T cells and NK cells express CD8 αα

homodimers. CD8 plays important roles in T cell activation and selection. The extracellular

IgSF domain of CD8α

binds to a non-polymorphic determinant on HLA class I molecules (α

3 domain) and enables CD8 to function as a

co-receptor with MHC class I-restricted TCR during T cell recognition of antigen. The cytoplasmic domain of CD8α

associates with Lck, a

Src family protein tyrosine kinase that is involved in intracellular signaling. The RPA-T8 and HIT8a (Cat. No. 555337) monoclonal antibodies

are not cross-blocking.

The antibody was conjugated to BD Horizon™ BV711 which is part of the BD Horizon™ Brilliant Violet™ family of dyes. This dye is a

tandem fluorochrome of BD Horizon™ BV421 with an Ex Max of 405-nm and an acceptor dye with an Em Max at 711-nm. BD Horizon™

BV711 can be excited by the violet laser and detected in a filter used to detect Cy™5.5 / Alexa Fluor® 700-like dyes (eg, 712/20-nm filter).

Due to the excitation and emission characteristics of the acceptor dye, there may be moderate spillover into the Alexa Fluor® 700 and

PerCP-Cy™5.5 detectors. However, the spillover can be corrected through compensation as with any other dye combination.

注意事项：

1.This reagent has been pre-diluted for use at the recommended Volume per Test. We typically use 1 × 10^6 cells in a 100-μl experimental
sample (a test).
2.Since applications vary, each investigator should titrate the reagent to obtain optimal results.
3.Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.