Hu CD324/E-Cadherin PerCPCy5.5 67A4 50T

产品编号：BD-563573 品牌：BD-Pharmingen 原厂货号：563573
产品分类：抗体 > 一抗 > 染料标记抗体
应用分类：

包装：

50T

运保温度:

Store undiluted at 4°C

到货周期：

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描述：

The 67A4 monoclonal antibody recognizes the extracellular domain of human E-Cadherin (CD324). E-Cadherin is a 120-kDa transmembrane
glycoprotein that is localized in the adherens junctions of epithelial cells. There it interacts with the cytoskeleton through the associated
cytoplasmic catenin proteins. In addition to being a calcium-dependent adhesion molecule, E-Cadherin is also a critical regulator of epithelial
junction formation. Its association with catenins is necessary for cell-to-cell adhesion. These E-Cadherin/catenin complexes associate with
cortical actin bundles at both the zonula adherens and the lateral adhesion plaques. Tyrosine phosphorylation can disrupt these complexes,
leading to changes in cell adhesion properties. E-Cadherin expression is often down-regulated in highly invasive, poorly differentiated
carcinomas. Increased expression of E-Cadherin in these cells reduces their invasiveness. Thus, loss of expression or function of E-Cadherin
appears to be an important step in tumorigenic progression. Pluripotent stem cells express E-Cadherin. Upon differentiation, an epithelial to
mesenchymal transition results in the loss of E-cadherin expression and a gain in the expression of N-cadherin.

注意事项：

1.This reagent has been pre-diluted for use at the recommended Volume per Test. We typically use 1 × 10^6 cells in a 100-μl experimental
sample (a test).
2.Since applications vary, each investigator should titrate the reagent to obtain optimal results.
3.Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.