Hu IFN-Gma BUV395 B27 50Tst

产品编号：BD-563563 品牌：BD-Pharmingen 原厂货号：563563
产品分类：抗体 > 一抗 > 染料标记抗体
应用分类：

包装：

50Tst

运保温度:

Store undiluted at 4°C

到货周期：

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描述：

The B27 monoclonal antibody specifically binds to human interferon-γ (IFN-γ). IFN-γ is a potent multifunctional cytokine that is produced
by several activated cell types including NK, NKT, CD4+TCRαβ+, CD8+TCRαβ+, and TCRγδ+ T cells. IFN-γ exerts its biological effects
through specific binding to the high-affinity IFN-γ Receptor Complex comprised of IFN-γRα (CD119) and IFN-γRβ subunits. In addition to
its antiviral effects, IFN-γ upregulates a number of lymphoid cell functions including the antimicrobial and antitumor responses of
macrophages, NK cells, and neutrophils. In addition, IFN-γ can exert strong regulatory influences on the proliferation, differentiation, and
effector responses of B cell and T cell subsets. These influences can involve IFN-γ’s capacity to boost MHC class I and II expression by
antigen-presenting cells as well as to direct effects on B cells and T cells themselves. Human IFN-γ is a 14-18 kDa glycoprotein containing
143 amino acid residues. B27 is a neutralizing antibody. The use of B27 antibody for epitope mapping of human IFN-γ has been described.
The B27 antibody has been reported not to bind to denatured IFN-γ.
The antibody was conjugated to BD Horizon™ BUV395 which has been exclusively developed by BD Biosciences as an optimal dye for use
on a 355 nm laser equipped instrument. With an Ex Max at 348 nm and an Em Max at 395 nm, this dye has virtually no spillover into any
other detector. BD Horizon™ BUV395 can be excited with a 355 nm laser and detected with a 379/28 filter.

注意事项：

1.Since applications vary, each investigator should titrate the reagent to obtain optimal results.
2.Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing. .
3.Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.