Hu Notch1 PE MHN1-519 50Tst

产品编号：BD-563421 品牌：BD-Pharmingen 原厂货号：563421
产品分类：抗体 > 一抗 > 染料标记抗体
应用分类：

包装：

50Tst

运保温度:

Store undiluted at 4°C

到货周期：

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描述：

The MHN1-519 monoclonal antibody specifically binds to an extracellular domain of human Notch1. Notch1 is a type 1 transmembrane

glycoprotein receptor and member of the Notch family that includes Notch1-Notch4. Notch1 is cleaved in the Golgi and presents as a cell

surface heterodimeric receptor. The Notch1 receptor can bind to several membrane-bound ligands including Jagged1, Jagged2, Delta1 and

Delta4. Upon ligand binding, Notch1 undergoes proteolytic cleavage that results in the release of the Notch intracellular domain, NICD. NICD

translocates to the nucleus where it forms a transcriptional activator complex with various transcriptional factors. These multimeric complexes

either positively or negatively regulate the expression of multiple genes including those that orchestrate many facets of embryonic

development and the subsequent functioning of multiple organ systems such as the immune, cardiovascular and nervous systems. Within the

immune system, Notch signaling significantly affects the development, proliferation, differentiation and survival of numerous cell types

including thymocytes and subsets of T and B lymphocytes and dendritic cells. In altered forms, Notch1 has been associated with certain

cardiovascular diseases and with some lymphocyte neoplasms.

注意事项：

1.This reagent has been pre-diluted for use at the recommended Volume per Test. We typically use 1 × 10^6 cells in a 100-μl experimental
sample (a test).
2.Since applications vary, each investigator should titrate the reagent to obtain optimal results.
3.Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.