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Hu CD8 BV510 RPA-T8 50Tst

Hu CD8 BV510 RPA-T8 50Tst

产品编号：BD-563256 品牌：BD-Pharmingen 原厂货号：563256
产品分类：抗体 > 一抗 > 染料标记抗体
应用分类：

包装：

50Tst

运保温度:

Store undiluted at 4°C

到货周期：

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描述：

The RPA-T8 monoclonal antibody specifically binds to CD8 alpha (CD8α

). CD8α

is a type I transmembrane glycoprotein and a member of

the immunoglobulin superfamily. CD8α

is expressed by the majority of thymocytes, by subpopulations of

αB

T cells and

γδ

T cells and by

some NK cells. Cell surface CD8

is expressed either as a disulfide-linked homodimer (CD8

αα

) or as a heterodimer (CD8

αβ

) when

disulfide-bonded to a CD8 beta chain (CD8

). CD8-positive

αβ

T cells coexpress both CD8

αα

homodimers and CD8

αβ

heterodimers whereas

some

γδ

T cells and NK cells express CD8αα

homodimers. CD8 plays important roles in T cell activation and selection. The extracellular

IgSF domain of CD8α

binds to a non-polymorphic determinant on HLA class I molecules (

3 domain) and enables CD8 to function as a

co-receptor with MHC class I-restricted TCR during T cell recognition of antigen. The cytoplasmic domain of CD8

associates with Lck, a

Src family protein tyrosine kinase that is involved in intracellular signaling. The RPA-T8 and HIT8a (Cat. No. 555337) monoclonal antibodies

are not cross-blocking.

The antibody was conjugated to BD Horizon™ BV510 which is part of the BD Horizon™ Brilliant Violet™ family of dyes. With an Ex Max

of 405-nm and Em Max at 510-nm, BD Horizon™ BV510 can be excited by the violet laser and detected in the BD Horizon™ V500

(525/50-nm) filter set. BD Horizon™ BV510 conjugates are useful for the detection of dim markers off the violet laser.

注意事项：

1.Since applications vary, each investigator should titrate the reagent to obtain optimal results.
2.Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing. .
3.Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.