Ms Notch2 PE 16F11 100ug

• 产品编号：BD-562755      品牌：BD-Pharmingen       原厂货号：562755
• 产品分类：抗体 > 一抗 > 染料标记抗体
• 应用分类：

描述：

The 16F11 monoclonal antibody specifically binds to the extracellular domain of Notch2. This Type 1 transmembrane protein is a member of
the Notch family that includes Notch1-4. Notch ligands include membrane-bound Jagged1, Jagged2 and Delta-like1, 3 and 4. Notch receptors
mediate juxtacrine signals between adjacent cells. Upon ligand binding, Notch2 undergoes proteolytic cleavage that results in the release of
the Notch intracellular domain, NICD. NICD translocates to the nucleus where it forms a transcriptional activator complex with the RBP-J
DNA binding factor and other transcriptional cofactors. These multimeric complexes regulate the expression of multiple genes including those
that orchestrate many facets of embryonic development and the subsequent functioning of cells within multiple organ systems. Notch2 is
expressed on bone marrow cells, DN1 and DN2 thymocytes, B cells and activated T cells. Notch2 plays multiple roles in the immune system
including the development of marginal zone B cells and the regulation of granzyme B expression by CD8+ T cells. In altered forms, Notch2
has been implicated in cellular transformation or progression in various neoplasms.
 

原厂资料：

注意事项：

1.Since applications vary, each investigator should titrate the reagent to obtain optimal results.
2.Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing.
3.Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.
4.The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.
5.The antibody was conjugated with R-PE under optimum conditions, and unconjugated antibody and free PE were removed.