The Q31-378 monoclonal antibody recognizes RORgamma t (RORγt), an isoform of RORgamma (RORγ). RORγt is a DNA-binding
transcription factor that belongs to the ROR/RZR orphan nuclear receptor family. RORγt is expressed exclusively by lymphoid cells including
CD4+CD8+ thymocytes, peripheral CD4+ Th17 and CD8+ Tc17 cells, NKT cells and innate lymphoid cells such as lymphoid tissue inducer
(LTi) cells. RORγt plays essential roles in thymopoiesis, T cell homeostasis, differentiation of effector T lymphocytes and the development of
secondary lymphoid tissues including lymph nodes and Peyer’s patches.
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注意事项:
1.Since applications vary, each investigator should titrate the reagent to obtain optimal results.