Themis Pure Q13-1103 50ug

• 产品编号：BD-562587      品牌：BD-Pharmingen       原厂货号：562587
• 产品分类：抗体 > 一抗 > 蛋白特异性一抗
• 应用分类：

描述：

The Q13-1103 monoclonal antibody specifically binds to human THEMIS (Thymocyte-expressed molecule involved in selection). The human
THEMIS gene encodes a 73-kDa signaling protein that is also known as thymocyte selection pathway associated (TSEPA), signaling
phosphoprotein specific for T cells (SPOT) and GRB2-associated protein (GASP). The homologous mouse protein is encoded by the Themis
gene. THEMIS mRNA is detected in the thymus, lymph nodes, spleen but not in the bone marrow or nonlymphoid tissues. It is expressed by
all thymocytes including double- (high levels) and single-positive αβ T cells, γδ T cells and peripheral T cells (low levels) but not by B cells
and NK cells. THEMIS plays a central role in T cell development including positive and negative selection processes in the thymus. It is
involved in TCR signaling and gets phosphorylated quickly after TCR stimulation. In the mouse system, Themis-deficient double-positive
thymocytes reportedly expressed lower levels of genes involved in later stages of T cell development including those related to cellular
metabolism, cell cycle and survival functions. Themis-deficient thymocytes showed impaired selection that lead to the production of fewer
mature thymocytes. The Q13-1103 antibody crossreacted with mouse Themis in Western blot testing of cellular lysates but did not crossreact
when tested by immunofluorescent staining and flow cytometric analysis of cells.
 

原厂资料：

注意事项：

1.Since applications vary, each investigator should titrate the reagent to obtain optimal results.
2.Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before
discarding to avoid accumulation of potentially explosive deposits in plumbing.
3.Store undiluted at 4°C.