Ronin/THAP11 Pure P56-507 100ug

产品编号：BD-562548 品牌：BD-Pharmingen 原厂货号：562548
产品分类：抗体 > 一抗 > 蛋白特异性一抗
应用分类：

包装：

100ug

运保温度:

Store undiluted at 4°C.

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描述：

Thanatos-associated proteins (THAPs) are characterized by the THAP domain, which is a conserved Drosophila P element transposase
DNA-binding domain. THAPs are DNA-binding factors involved in cell proliferation, apoptosis, cell cycle and transcriptional regulation.
THAP11 is an essential factor in embryogenesis and ES cell pluripotency and binds directly to host cell factor 1 (HCF-1), a key regulator of
transcriptional control. THAP11 has been designated as Ronin, named for a masterless Japanese samurai because of its lack of any apparent
relationship to Nanog, Oct4 and Sox2—the master regulators of pluripotency. Ronin/THAP11 binds to the c-Myc promoter and
down-regulates c-Myc expression. Recently, it was reported that Bcr-Abl inhibited the expression of THAP11 in Chronic myelogenous
leukemia (CML) cells and promoted CML cell proliferation by the aberrant induction of c-Myc expression.

注意事项：

1.Since applications vary, each investigator should titrate the reagent to obtain optimal results.
2.Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before
discarding to avoid accumulation of potentially explosive deposits in plumbing.
3.Store undiluted at 4°C.