The Eat2 monoclonal antibody specifically binds to CD81, a 26-kDa nonglycosylated member of the transmembrane 4 integral membrane
protein superfamily, expressed by many types of cells. For example, CD81 participates with CD19 and CD21 in the signal transduction
complex associated with the B-cell receptor on human B lymphocytes and with the CD4 and CD8 co-receptors on human thymocytes and T
lymphocytes. In mouse fetal thymic organ culture, interactions of immature thymocytes with CD81 expressed by thymic stromal cells are
required to induce development of T cells with αβ T-cell receptors. Furthermore, CD81 has been shown to play a role in the regulation of rat
mastcell degranulation. Despite its important roles in the immune response and wide tissue distribution, CD81-deficient mice are born
without obvious developmental abnormalities. However, these mice have abnormal immune responses, and impaired fertility. Eat2 mAb
cross-reacts with the rat CD81 antigen. Eat2 mAb was reported cross-reacting with the rat CD81 antigen.
原厂资料：
注意事项：
1.Since applications vary, each investigator should titrate the reagent to obtain optimal results.
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