Rat CD8B NALE 341 500ug

• 产品编号：BD-562210      品牌：BD-Pharmingen       原厂货号：562210
• 产品分类：抗体 > 一抗 > 蛋白特异性一抗
• 应用分类：

描述：

The 341 antibody reacts with the β chain of the CD8 antigen on most thymocytes and a subpopulation of mature T lymphocytes (ie, MHC
class I-restricted T cells, including most T suppressor/cytotoxic cells). The CD8 α and β chains (CD8a and CD8b, respectively) form a
heterodimer on the surface of most thymocytes and thymus-dependent T suppressor/cytotoxic cells, whereas intestinal intraepithelial
lymphocytes, many CD8+ T cells of athymic rats, many activated CD4+ T cells, and most NK cells express CD8a without CD8b. It has been
suggested that the expression of the CD8a/CD8b heterodimer is restricted to thymus-derived T lymphocytes. CD8 is an antigen co-receptor on
the T cell surface which interacts with MHC class I molecules on antigen-presenting cells. It participates in T-cell activation through its
association with the T-cell receptor complex and protein tyrosine kinase lck. Macrophages have also been reported to express CD8 α and β
chains, which are involved in signal transduction. The 341 mAb blocks proliferative and cytotoxic in vitro responses of CD8+ effectors to
allogeneic cells.
 

原厂资料：

注意事项：

1.Since applications vary, each investigator should titrate the reagent to obtain optimal results.

2.Store undiluted at 4°C.