Hu MIC A/B NALE 6D4 500ug

• 产品编号：BD-562202      品牌：BD-Pharmingen       原厂货号：562202
• 产品分类：抗体 > 一抗 > 蛋白特异性一抗
• 应用分类：

描述：

The 6D4 monoclonal antibody specifically binds to the human MHC class I polypeptide-related sequence A (MICA, aka PERB11.1) and B
(MICB. aka PERB11.2) proteins. These ~70 kDa transmembrane glycoproteins are homologs of the major histocompatibility complex class I
molecules although they lack association with β2 microglobulin. The MHC class I-related MICA and MICB chains are expressed by some gut
epithelial cells in vivo. MICA and MICB expression by other epithelial cells and cell types, including fibroblasts and endothelial cells, is
induced by stress, eg, stress caused by bacterial and viral infections, autoimmunity or cellular transformation. Epithelial cell expression of
MICA and MICB has also been detected in transplanted kidneys and pancreas that show histological signs of rejection and or cellular injury.
This suggests their potential role in transplant immunopathology. MICA and MICB are ligands for NKG2D (CD314), an activating receptor
expressed by natural killer (NK) cells, γδ T cells, CD8+ and some CD4+ αβ T cells. The 6D4 antibody reportedly blocks NKG2D-positive
NK cell- and T cell-mediated cytotoxicity against MICA/B-positive target cells.

原厂资料：

注意事项：

1.Since applications vary, each investigator should titrate the reagent to obtain optimal results.

2.Store undiluted at 4°C.