Hu CD271 PE-Cy7 C40-1457 50Tst

• 产品编号：BD-562122      品牌：BD-Pharmingen       原厂货号：562122
• 产品分类：抗体 > 一抗 > 染料标记抗体
• 应用分类：

描述：

The C40-1457 monoclonal antibody specifically reacts with CD271, the nerve growth factor receptor (NGFR). CD271 is a transmembrane 75
kDa protein that has been found localized to neuronal axons, Schwann cells, and perineural cells of peripheral nerves. It is also expressed by
cells in some epithelial, mesenchymal and lymphoid tissues. NGFR is the receptor for nerve growth factor (NGF), a polypeptide that is
essential for normal development of the nervous system. NGF promotes survival and differentiation of sympathetic and sensory neurons
during embryological development of peripheral neurons. NGF binds to two distinctive surface receptors expressed by target cells, the
p140-TrkA (NTRK1) and the p75 NGFR. High affinity binding of NGF requires that both receptor molecules be expressed. NGFR has been
found on human and rat lymphocytes. A subset of lymphoid cells in the spleen, lymph nodes, and follicular dentritic cells in germinal centers
of reactive lymph nodes were found to express CD271. It has been reported that NGFR interaction with its ligand, NGF, may play a role in
immunoregulation. NGF may function as a B-cell growth factor.
 

原厂资料：

注意事项：

1.This reagent has been pre-diluted for use at the recommended Volume per Test. We typically use 1 × 10^6 cells in a 100-μl experimental
sample (a test).
2.Since applications vary, each investigator should titrate the reagent to obtain optimal results.
3.Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.