Hu CD8 APC-Cy7 SK1 25Tst

• 产品编号：BD-561945      品牌：BD-Pharmingen       原厂货号：561945
• 产品分类：抗体 > 一抗 > 染料标记抗体
• 应用分类：

描述：

CD8 recognizes the 32-kDa a-subunit of a disulfide-linked bimolecular complex. The majority of peripheral blood CD8+ T lymphocytes
express an a/b heterodimer (Mr 32, 30 kDa), while CD8+CD16+ natural killer (NK) lymphocytes and CD8+ T-cell receptor (TCR)-γ/δ+
lymphocytes express a/a homodimer (Mr 30 kDa). CD8+TCR-α/β+ lymphocytes can express either an α/α homodimer or α/β heterodimer. The
CD8 antigenic determinant binds to class I major histocompatibility (MHC) molecules resulting in increased adhesion between the CD8+ T
lymphocytes and target cells. Binding of the CD8 antigen is coupled to a protein tyrosine kinase p56lck. The CD8:p56lck complex can play a
role in T-lymphocyte activation through mediation of the interactions between the CD8 antigen and the CD3/TCR complex.
The CD8 antigen is present on the human suppressor/cytotoxic T-lymphocyte subset, as well as on a subset of NK lymphocytes. The CD8
antigen is expressed on 19% to 48% of normal peripheral blood lymphocytes and 60% to 85% of normal thymocytes. The CD8+ T- and
NK-lymphocyte subsets can be further subdivided into the following groups: CD16+ and NK lymphocytes that can express the CD8 antigen in
low density; CD57+ T lymphocytes that express high-density CD8 antigen; and CD8+ CD62L+ lymphocytes that collaborate with
CD8+CD62L- lymphocytes to generate suppression of B-lymphocytes function. CD8 cross-reacts with lymphocytes of some nonhuman
primate species.
 

原厂资料：

注意事项：

1.This reagent has been pre-diluted for use at the recommended Volume per Test. We typically use 1 × 10^6 cells in a 100-μl experimental
sample (a test).
2.Since applications vary, each investigator should titrate the reagent to obtain optimal results.
3.Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.