Ms IL-17F Alexa 488 O79-289 25ug

• 产品编号：BD-561658      品牌：BD-Pharmingen       原厂货号：561658
• 产品分类：抗体 > 一抗 > 染料标记抗体
• 应用分类：

原厂资料：

The O79-289 monoclonal antibody specifically binds to the inflammatory cytokine protein, Interleukin-17 (IL-17F). IL-17F is a member of
the IL-17 family of cytokines. Among IL-17 family members, IL-17F has the highest amino acid sequence homology to IL-17A. IL-17F is
produced by activated CD4+ T helper (Th17) cells, CD8+ T (Tc17) cells and γδ T cells. IL-17F can be secreted as homodimers or as
heterodimers with IL-17A. IL-17F and IL-17A have overlapping functions such as inducing epithelial cells and fibroblasts to produce
proinflammatory cytokines and chemokines including IL-6, GM-CSF, CXCL1, CCL2, and CCL7. These factors attract and activate
neutrophils and other cell types that mediate protective responses against pathogenic microbes or pathologic allergic or autoimmune diseases.
IL-17 gene knockout studies have shown that IL-17F and IL-17A have independent functions as well. IL-17F and IL-17A exert their
biological function by binding to and signaling through IL-17 receptors comprised of the transmembrane receptor subunits, IL-17RA (CD217)
and IL-17RC.

注意事项：

1. Since applications vary, each investigator should titrate the reagent to obtain optimal results.

2.An isotype control should be used at the same concentration as the antibody of interest.

3.Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing.

4.The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.
5.The antibody was conjugated to Alexa Fluor® 488 under optimum conditions, and unreacted Alexa Fluor® 488 was removed.
6.Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.