BCL-6 Pure K112-91 100ug

产品编号：BD-561520 品牌：BD-Pharmingen 原厂货号：561520
产品分类：抗体 > 一抗 > 蛋白特异性一抗
应用分类：

包装：

100ug

运保温度:

Store undiluted at 4°C.

到货周期：

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描述：

The K112-91 monoclonal antibody specifically binds to Bcl-6. Bcl-6 was first identified as a proto-oncogene frequently deregulated by
chromosomal translocations in non-Hodgkin B-cell lymphomas. It is a nuclear transcriptional repressor of the BTB/POZ zinc-finger family of
transcription factors. In addition to its role in cancer, Bcl-6 plays an important role in normal lymphocyte differentiation. Bcl-6 is highly
expressed in germinal center B cells, where it promotes the germinal center reaction by inducing proliferation and inhibiting the DNA-damage
response. Additionally, Bcl-6 has been identified as a key factor in promoting the differentiation of CD4+ follicular T helper (Tfh) cells, which
are involved in promoting germinal center formation and providing help to B cells. The interplay of Bcl-6 and another transcriptional
repressor, Blimp-1, is thought to be critical in defining the results of both B-cell and T-cell differentiation.

注意事项：

1.Since applications vary, each investigator should titrate the reagent to obtain optimal results.
2.Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before
discarding to avoid accumulation of potentially explosive deposits in plumbing.
3.Store undiluted at 4°C.