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T-BET Horizon V450 O4-46 50Tst

T-BET Horizon V450 O4-46 50Tst

产品编号：BD-561312 品牌：BD-Pharmingen 原厂货号：561312
产品分类：抗体 > 一抗 > 染料标记抗体
应用分类：

包装：

50Tst

运保温度:

Store undiluted at 4°C

到货周期：

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描述：

The O4-46 monoclonal antibody specifically binds to human and mouse T-bet. T-bet (T-box gene expressed in T cells) is a master regulatory

transcription factor that is also known as TBX21 (T-box21) and TBLYM (T-box transcription factor, expressed in lymphocytes). Human (535

amino acids; 58.3 kDa predicted molecular mass) and mouse (530 amino acids; 57.7 kDa) T-bet proteins are encoded by the human

TBX21

(chromosome 17) and mouse

Tbx21

(chromosome 11) genes. The human and mouse T-bet protein amino acid sequences are 88% homologous.

Human and mouse T-bet proteins share a highly conserved (98% homologous amino acid sequences) T-box protein domain that is centrally located

and mediates binding to DNA. T-bet is expressed by and activates transcriptional activities within hemotopoietic cells including stem cells, NK

and NKT cells and subsets of thymocytes, primed/activated CD4+ T cells, CD8+ T cells and

γδ T cells, B cells, and dendritic cells.

Interferon-gamma (IFN-γ), interleukin-27 (IL-27), and IL-12 act on peripheral antigen-triggered (TCR-signaling) T cells to increase T-bet

expression. With respect to T helper lymphocytes, T-bet directs the differentiation of naïve CD4+ precursor T cells to become Th1-like effector and

memory cells. T-bet accomplishes this by activating Th1 genetic programs (including epigenetic modifications) while repressing opposing T helper

subset programs. T-bet controls the upregulated expression of the Th1 signature cytokine, IFN-

γ, the IL-12Rβ

2 subunit and the Runx3 transcription

factor and can repress the function of other transcriptional regulators, such as GATA-3 (master regulator of Th2 development) and the expression

of other cytokines including IL-2, IL-4 and IL-5.

The antibody is conjugated to BD Horizon™ V450, which has been developed for use in multicolor flow cytometry experiments and is

available exclusively from BD Biosciences. It is excited by the Violet laser Ex max of 406 nm and has an Em Max at 450 nm. Conjugates with

BD Horizon™ V450 can be used in place of Pacific Blue™ conjugates.

注意事项：

1.This reagent has been pre-diluted for use at the recommended Volume per Test. We typically use 1 × 10^6 cells in a 100-μl experimental
sample (a test).
2.Since applications vary, each investigator should titrate the reagent to obtain optimal results.
3.Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.