Ms IFN Receptor 1 NALE MAR1-5A3 500ug

• 产品编号：BD-561183      品牌：BD-Pharmingen       原厂货号：561183
• 产品分类：抗体 > 一抗 > 蛋白特异性一抗
• 应用分类：

描述：

The MAR1-5A3 monoclonal antibody specifically binds to the IFN-α/β Receptor 1 (also known as Interferon-alpha/beta Receptor 1; Type I
Interferon Receptor 1 or IFNAR-1) subunit. A variety of cell types including lymphocytes, monocytes/macrophages, dendritic cells, and
fibroblasts can be stimulated or induced by viral and microbial infections to produce and secrete type I interferons, including Interferon-alpha
(IFN-α) subtypes and Interferon-beta (IFN-β). IFN-α subtypes and IFN-β bind to a common heterodimeric receptor complex (also known as
the Type I IFN Receptor or IFN-α/β Receptor) that is comprised of transmembrane glycoprotein IFNAR-1 and IFNR-2 subunits and is
expressed on most cell types. Upon ligand binding, IFNAR-1 and IFNAR-2 signal cellular responses. Type I interferons are multifunctional
proteins that can induce antiviral states in cells as well as regulate the activation, growth, proliferation, differentiation and viability of various
cell types including cells that mediate innate and adaptive immunity as well as autoimmune diseases. The MAR1-5A3 monoclonal antibody
blocks Type I IFN receptor signaling and in vitro and in vivo biologic responses caused by type I interferons. The MAR1-5A3 antibody has
also been reported to be useful for immunofluorescent staining and flow cytometric analysis, immunoprecipitation and Western blot analysis
of IFNAR-1.

原厂资料：

注意事项：

1.Since applications vary, each investigator should titrate the reagent to obtain optimal results.
2.Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before
discarding to avoid accumulation of potentially explosive deposits in plumbing.
3.Store undiluted at 4°C.