Rat TNF OptEIA ELISA Kit 2Plt

产品编号：BD-560479 品牌：BD-Pharmingen 原厂货号：560479
产品分类：ELISA及其它免疫分析 > ELISA > ELISA检测试剂盒
应用分类：

包装：

2Plt

运保温度:

. Store the unopened kit at 2 - 8°C

到货周期：

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描述：

Tumor necrosis factor (TNF, formerly known as TNF-α) is a potent mediator of immune and inflammatory responses.1-2 TNF is produced by many activated cell types including monocytes, macrophages, astrocytes, granulocytes, T and B lymphocytes, NK cells, keratinocytes, fibroblasts, and certain tumor cells. TNF exerts many regulatory influences on the activation, growth, and differentiation of leukocytes and other cells. For example, TNF can costimulate the proliferation of activated T and B lymphocytes, upregulate the expressed levels of MHC class I and class II molecules by various cell types, as well as induce the expression of adhesion molecules by endothelial cells. TNF is selectively cytotoxic for some transformed cell lines and can exert cytotoxic effects against certain solid tumors. In vivo, TNF serves as a primary mediator in protective immune responses against microbial and viral pathogens. However, TNF has also been implicated as a central mediator in a number of pathologic responses including septic shock, cachexia, and autoimmune diseases.
Activated cells initially express TNF as transmembrane proteins that associate to form homotrimeric complexes. After proteolytic cleavage, the extracellular region of membrane TNF sheds as a soluble homotrimer. Both Membrane and soluble TNF homotrimers are biologically active, whereas monomeric TNF is not. The mature rat TNF monomer contains 157 amino acid residues has a predicted size of ~17 kDa.3 TNF exerts its biological activities by binding and signaling through membrane Type I and II TNF Receptors (TNFRI and TNFRII). Interestingly, TNF binds to soluble forms of TNFR (sTNFRI and sTNFRII) which are naturally shed by activated cells and can modulate biological activities of TNF.
The BD OptEIA™ Rat TNF ELISA Kit is for the quantitative determination of TNF in rat serum, plasma, and cell culture supernatant.

注意事项：

1. Store the unopened kit at 2 - 8°C. Do not use the kit after the
expiration date.
2. Before use, bring all reagents to room temperature (18 - 25°C).
Immediately after use, return to proper storage conditions.
3. Lyophilized standards are stable until the kit expiration date. After
reconstitution, use freshly reconstituted standard within 12 hours
(stored at 2 - 8°C).